STUDY ON THE INHIBITIVE EFFECT OF BONE LOSS BY SOYBEAN ISOFLAVONE IN OVARIECTOMIZED RATS
- VernacularTitle:大豆异黄酮对去势大鼠骨量丢失的抑制作用研究
- Author:
Xiaolin NA
;
Xiumei LIU
;
Hongbin CUI
- Publication Type:Journal Article
- Keywords:
soybean isoflavone;
bone loss;
ovariectomized rats
- From:
Acta Nutrimenta Sinica
1956;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the inhibitive effect of soybean isoflavone on bone loss induced by the decrease of estrogen level in ovariectomized rats. Methods: Ovariectomized Wistar rats (n=48) were divided into six groups and given basic diet, or containing soybean isoflavone or diethylstilbestrol diet. After 16 weeks,estrogen and TRAP (tartrate -resistant acid phosphatase) and BGP (bone Gla-containing protein) in serum were determined. BMD (bone mineral density), bone calcium and phosphorus were measured. By using scanning electron microscope and histochemistry methods to observe the change of microstructure in trabecular bone. Result: Soybean isoflavone can significantly decrease the activity of bone resorption marker TRAP and increase the content of bone formation marker BGP. Soybean isoflavone posses weak estrogen effect and increase femur BMD and Ca, P content. Conclusion:Soybean isoflavone have significantly effect of anti-bone loss in ovariectomized rats.
