EFFECT OF SOYASAPONINS IN PREVENTION OF HYPERLIPIDEMIA IN MICE AND ITS MOLECULAR MECHANISM
- VernacularTitle:大豆皂甙预防小鼠高脂血症的作用及其分子机制研究
- Author:
Junxia XIAO
;
Guanghua PENG
;
Shenghua ZHANG
- Publication Type:Journal Article
- Keywords:
soyasaponins;
hyperlipidemia;
antioxidation;
gene expression
- From:
Acta Nutrimenta Sinica
1956;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate effect of soyasaponins in the prevention of hyperlipidemia in mice and its molecular mechanism. Methods: 56 healthy mice were randomly divided into 7 groups according to their levels of TC in serum: normal control, high fat control, high fat with 20mg/kg.d gypenosides,high fat with soyasaponins of four doses(5 mg/kg.d, 10mg/kg.d, 20mg/kg.d, 30 mg/kg.d). Results: As compared to high fat control soyasaponins significantly reduced the serum TC, LDL-C, TG concentrations, and increased the HDL-C levels distinctly. They significantly deceased MDA content, increased the activities of SOD and LPL in liver. The results of RT-PCR showed that high fat feeding could induce the reduction of LPL mRNA expression, while soyasaponins could increase it. Conclusion: Soyasoponins prevent hyperlipidemia through upregulation of LPL mRNA expression and increase of antioxidative capacity.
