THE ANTIHYPERGLYCEMIC EFFECT OF FLAVONOIDS FROM HIPPOPHAE RHAMNOIDES L.ON DIABETIC RATS INDUCED BY STREPTOZOTOCIN
- VernacularTitle:沙棘黄酮对链脲佐菌素致糖尿病大鼠降糖作用
- Author:
Qunhua CAO
;
Weijing QU
;
Wei NIU
;
Yunxia DENG
;
Yiwen WANG
;
Jingjing XIE
- Publication Type:Journal Article
- Keywords:
flavonoids from Hippophae rhamnoides L.;
diabetes;
fructosamine;
serum protein
- From:
Acta Nutrimenta Sinica
1956;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the antihyperglycemic effect of flavonoids from seed (FSH) and fruit(FFH) of Hippophae rhamnoides L.on diabetic rats induced by streptozotocin (STZ). Methods: The STZ-induced diabetic rats were randomly divided into four groups and were given intragastrically (ig) water, metformin, FSH and FFH respectively once a day. After four weeks, the levels of serum glucose, fructosamine, lipid, protein, GSH and lactic acid (LD) were assayed. Results: FSH could reduce the levels of serum glucose, fructosamine and triglyceride significantly, increase the contents of serum total protein and albumin obviously, enhance the ability of antioxidation in STZ-induced diabetic rats. FSH also could decrease food and water intake of diabetic rats evidently. But FSH had little effect on LD, LDH, glycogen and body weight in diabetic rats. FFH was not as good as FSH. Conclusion: FSH is antihyperglycemic , and can improve the metabolic derangements of STZ- induced diabetic rats.
