Host factors that influence the progression from chronic hepatitis C virus infection to liver cirrhosis
- VernacularTitle:丙型肝炎病毒感染至肝硬变进程影响因素的分析
- Author:
Tao YAN
;
Wei JI
;
Huifen WANG
- Publication Type:Journal Article
- Keywords:
hepatitis C virus;
infection;
influential factors;
liver cirrhosis
- From:Journal of Third Military Medical University
2003;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the influence of host factors on the progression to cirrhosis in patients with chronic hepatitis C virus (HCV) infection. Methods Duration of 121 patients from HCV infection developing to liver cirrhosis was compared according to age at which HCV was infected, having the history of acute hepatopathy or not, infection pathway and sex. Patients with other hepatitis virus infection were excluded. Age, at which HCV was infected, was identified as that at blood transfusion or acute episode in non-transfusion patients. No patients had applied to any drugs. Results It took mean (27.17?6.78) years for the patients of age range 0-20 at which HCV was infected to develop to cirrhosis, while only (10.16?5.84) years for those of age range 41～50. There were significant differences between them (P0.05). Conclusion Our data show that patients with older age at which HCV was infected, with history of acute hepatopathy or HCV infection through blood transfusion developed into liver cirrhosis in shorter time. Sex was not found to have significant influence on the progression to cirrhosis.
