Expression and secretion of SPARC in body fluid of patients with autosomal dominant polycystic kidney disease
- VernacularTitle:SPARC在常染色体显性多囊肾病患者体液中的表达及其分泌研究
- Author:
Wenjing WANG
;
Changlin MEI
;
Tianmei SUN
- Publication Type:Journal Article
- Keywords:
osteonectin;
polycystic kidney, autosomal dominant
- From:
Medical Journal of Chinese People's Liberation Army
1981;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the concentration of secreted protein acidic and rich in cysteine (SPARC) in body fluid of patients with autosomal dominant polycystic kidney disease (ADPKD) and the origin of its secretion. Methods The concentration of SPARC in plasma, urine and cystic fluid from patients with ADPKD and healthy individuals was measured with ELISA. The content of SPARC protein in the culture medium of cystic epithelial cells was detected by Western blot. Results The concentration of SPARC in cyst fluid of ADPKD patients [( 3 628.75? 1 445.90) ng/ml] was much higher than that in their plasma and urine (P
