Gene variations in the basic core promotor and the pre C/C region of hepatitis B virus
- VernacularTitle:乙型肝炎病毒前C/C区及其调控基因变异的研究
- Author:
Weifang LIANG
;
Haitang HE
;
Zhihua LIU
- Publication Type:Journal Article
- Keywords:
hepatitis B virus;
gene;
mutation
- From:
Medical Journal of Chinese People's Liberation Army
1981;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the mutants of pre C/C gene and the base core premotor (BCP) in chronic hepatitis B patients carrying or not carrying hepatitis B e antigen (HBeAg). Method The HBV DNA of BCP and PreC/C ware amplified by PCR from serum samples of patients with chronic hepatitis B, and the products were cloned into T vector and sequenced. Results Of BCP variants, the double mutations of T1762/ A1764 were found in 20 of 42 patients with chronic hepatitis, and the prevalence was significantly lower in HBeAg positive patients (7/20) than in HBeAg negative patients (13/22) (P
