An inquiry into mechanism of portal hypertension through comparative analysis of 150 cases of cirrhosis and portal hypertension undergoing emergent or elective surgical intervention
- VernacularTitle:肝硬化门脉高压症急症与择期手术治疗的病理比较及门脉高压症机制的探讨
- Author:
Wenshu LI
;
Deng PAN
;
Zhiwei LI
- Publication Type:Journal Article
- Keywords:
portal hypertension;
liver cirrhosis;
extensive esophagogastric devascularization;
acute;
clinic;
pathology;
mechanism
- From:
Medical Journal of Chinese People's Liberation Army
1981;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective Liver function in perioperative periods, postoperative complications, and pathological changes in the liver were studied and compared between patients undergoing emergent and elective surgical intervention (extensive esophagogastric devascularization, EED) for portal hypertension (PTH), with the purpose to elucidate the pathogenesis of PTH. Methods The clinical data and liver biopsies from 150 cases of inpatients with hepatis cirrhosis and PTH who underwent either emergent (28 cases) or elective (100 cases) surgical intervention including extensive esophagogastric devascularization (EED) in 302 th Hospital of PLA were analysed. Liver biopsy was done in 128 patients, and the expression of ?-smooth muscle actin (?-SMA), tubulin?and ?in hepatic stellate cells (HSCs), and endothelin-1 (ET-1) was histochemically studied in the liver tissue. Results It was found that the mean internal diameter of portal veins before surgery was larger and the incidence of pre-operative acute variceal haemorrhage was significantly higher in the emergent EED group than those in the elective EED group (P
