Roles of histone acetyltransferases and deacetylases in the process of cell proliferation,differentiation and tumorogenesis
- VernacularTitle:组蛋白乙酰化酶和去乙酰化酶在细胞增生分化和肿瘤发生中的作用
- Author:
Yaping YU
;
Xuewen WANG
- Publication Type:Journal Article
- From:
Journal of Medical Postgraduates
2001;14(3):249-251,254
- CountryChina
- Language:Chinese
-
Abstract:
Acetylation of lysine residues of core histone N-terminal domains has been found correlatively associated with transcriptional activation in eukaryotes. Recent studies showed that some transcriptional regulators with histone acetyltransferase(HAT) and deacetylase(HDAC) activities may play a causative role in regulating gene expression. The link between tumorigenic processes and misregulated or mistargeted HAT and HDAC activities has been reported.
