Distribution of stem cells of optic cup in rat embryos
- VernacularTitle:大鼠胚胎视杯干细胞的分布研究
- Author:
Xiaoyong HUANG
;
Zhengqin YIN
;
Shijun WANG
;
Yuxiao ZENG
- Publication Type:Journal Article
- Keywords:
embryo;
optic cup stem cell;
location
- From:Journal of Third Military Medical University
1988;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the location of embryonic optic cup stem cells during tailbud stage. Methods The embryonic optic cup at embryonic day 11～15 (E11～15) in rats was sectioned horizontally at 15 ?m thick. The distributive characteristics of embryonic optic cup progenitor cells were revealed by immunohistochemistry. Results ①The distribution of optic cup progenitors was mainly aggregated on the optic cup at E12.5. CHX10-positive cells were organized as stratified epithelium arrangement on optic cup inner layer. Clusters of CHX10-positive cells were observed at the edge of optic cup; ② Pigment appeared in the outer layer of optic cup at E13.5, and differentiation into ganglion cells was initiated. Conclusion The distribution of optic cup stem cells is mainly aggregated on the optic cup at E12.5 in which the differentiation into ganglion cells is not initiated.
