Studies on the relationship between prostaglandin E_2 and rheumatoid arthritis with drug development
- VernacularTitle:前列腺素E_2与类风湿关节炎及其药物研究
- Author:
Hongmei XU
;
Wei WEI
- Publication Type:Journal Article
- Keywords:
rheumatoid arthritis;
prostaglandin E_2;
cellular factors;
nonsteroid anti-inflammatory drugs
- From:
Chinese Pharmacological Bulletin
1987;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Rheumatoid arthritis (RA) is an autoimmunity disease, and many effect factors contribute to the pathogenesis process of RA. Prostaglandin E_2(PGE_2) is one major inflammatory mediator. In this article ,we review the synthesis,metabolism and action pathway of PGE_2, the interaction between PGE_2 and inflammatory cellular factors of RA, and the therapeutic effect of drugs on RA.
