Effects of bioactive compoundsfrom entomogenous fungi on depression mouse models
- VernacularTitle:一种白僵菌代谢产物提取物抗抑郁作用的研究
- Author:
Lanlan ZHOU
;
Liang MING
;
Chuangeng MA
;
Meizhen FAN
;
Yan CHENG
;
Qin JIANG
- Publication Type:Journal Article
- Keywords:
entomogenous fungi;
beauveria;
depression;
model;
monoamine neurotransmitter
- From:
Chinese Pharmacological Bulletin
1987;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To study the antidepressant effects of bioactive compounds from entomogenous fungi(BCEF) in mouse models of depression. Methods The antidepressant effects of Bioactive compounds from entomogenous fungi was examined on the chronic unpredictable stress test, yohimbine induced lethality test, and 5-HTP induced head-twitches test. Results BCEF(50 mg?kg~-1 , ig, qd?21 d)could significantly increase the crossing and rearing score in open-field test. After administration yohimbine 1 h, BCEF 100 mg?kg~-1 group mice mortality rate rising rapidly; BCEF(50,100 mg?kg~-1 ) could distinctly increase the head-twitch number in the 5-HTP induced head-twitches test. Conclusion BCEF has antidepressant effects in depression mouse models. The mechanisms of its antidepressant effects may be related with the reinforcement of central monoamine neurotransmitter especially to 5-HT and NE nerves system.
