Studies on pharmacokinetics of guanfu base I,a metabolite of guanfu base A
- VernacularTitle:盐酸关附甲素代谢产物关附壬素的药动学研究
- Author:
Xiaotian LI
;
Guangji WANG
;
Sujun WANG
;
Jinghan LIU
- Publication Type:Journal Article
- Keywords:
guanfu base I;
high performance liquid chromatography;
electrospray ionization mass spectrometry;
pharmacokinetics
- From:
Chinese Pharmacological Bulletin
1987;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To establish an analytical method for determination of guanfu base I (GFI) concentration in plasma and investigate its pharmacokinetics in rats. Methods Rats were given a 20 mg?kg~-1 dose intravenously. Blood samples were collected at various times after iv administration. The plasma concentration of GFI was determined by LC-MS. Pharmacokinetic parameters were calculated by 3p97 program.Results The method was linear in the 0.05～20 mg?L~-1 concentration range (r=~0.999 4 ). The recovery of guanfu base I was more than 80%.The intraday and interday precision, expressed as the relative standard deviation (RSD), was generally good (
