Effects of paroxetine on psychological stress induced by c-fos gene expression in rat hypothalamus paraventricular nucleus
- VernacularTitle:帕罗西汀对心理应激大鼠下丘脑室旁核c-fos表达的影响
- Author:
Huanjie HUANG
;
Bei SHAO
;
Rongyuan ZHENG
;
Jianmin LI
;
Zhiqin YAN
;
Liwei XIE
;
Zongmin WANG
- Publication Type:Journal Article
- Keywords:
paroxitine;
psychological stress;
c-fos;
cortisol hypothalamus;
paraventricular nucleus
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2000;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the effects of paroxetine on the psychological stress induced by c-fos gene expression in the rat hypothalamus paraventricular nucleus(PVN) and to explore the molecular mechanism of effects of paroxetine on the stress related anxiety disorders. METHODS: The rat psychological stress model was made by restraint stress. The cortisol was analyzed by radioimmnoassay, and expression of c-fos positive cells was detected by S-P immunohistochemical assay in the rat PVN. RESULTS: The level of cortisol and the expression of c-fos positive cells increased more significantly in the other groups than that in the control group, but decreased in the paroxetine group. The paroxetine reduced the level of cortisol and inhibited the expression of c-fos positive cells in the PVN after psychological stress. CONCLUSION: The paroxetine can regulate the nerve centre by alleviating the expression of the c-fos in the hypothalamus paraventricular nucleus(PVN)and the activation of HPA pathway.
