Protective effects of CN802 on immunological liver injury in mice
- VernacularTitle:中国拟青霉对小鼠免疫性肝损伤的保护作用
- Author:
Liang CHENG
;
Pingxiang XU
;
Yu TANG
- Publication Type:Journal Article
- Keywords:
paecilomyceps sinensis sp nov (CN-802);
immunological liver injury;
BCG;
LPS;
T- lymphocyte subsets
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2000;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the protect effects of paecilomyceps sinensis sp nov (CN-802) on immunological liver injury in mice which induced by BCG+LPS. METHODS: LPS was injected into mice via the tail vein pretreated with BCG. The activity of serum ALT, the weighing indexes of liver and spleen, the levels of LPO in serum and hepatic tissues, and the numbers of subgroup of T lymphocyte were determined respectively. RESULTS: CN-802 at dose of 1.0 g?kg -1?d -1 decreased the serum ALT level, the liver and spleen-enlarged index and the LPO levels in serum and hepatic tissues. Analysis of CD_4/CD_8 in the peripheral blood showed that CN-802 increased the number of CD_4 lymphocyte and the ratio of CD_4/CD_8. CONCLUTION: Pretreatment with CN-802 prevents the immunological liver injury induced by BCG+LPG, and the effect of CN802 may be related with the regulatory of immune cells.
