A method based on cumulative toxicity for evaluating pharmacokinetics of oral traditional Chinese medicine in animals
- VernacularTitle:用累积毒性原理评价口服中药体内过程
- Author:
Chengyu LU
;
Haiyan WANG
;
Zhong DAI
;
Bin DAI
;
Tie WU
- Publication Type:Journal Article
- Keywords:
traditional Chinese medicine;
pharmacokinetics;
acute cumulative death rates;
computer simulator;
absorption
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2000;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To improve the acute cumulative death rates method (ACD method) in animal by oral administration. METHODS: A mathematic model was established to evaluate the dose-toxic effect relationship by twice oral administration and the experimental steps were improved too. The methodological quality was explored using the simulation data from computer program and the real experimental date from the reference paper. RESULTS: The results showed that the experimental data could be fitted to its theoretical data from LD_5/2 to LD_ 95/2. Concentration-time curve after po ordinary powder of Semen Strychni in mice were fitted to a one-compartment with T_ 1/2(ka)= 1.136 h,T_ 1/2(ke)= 7.100 h,and T_ max= 3.576 h. CONCLUSION: The improved ACD method can be used in the pharmacokinetics of TCM by oral administration.
