Expressions of laminin and calmodulin and its significance in the metastasis and prognosis of non-small cell lung carcinoma
- VernacularTitle:层粘蛋白和钙调素蛋白在非小细胞肺癌中的表达及其与转移和预后的关系
- Author:
Guoxiang LIU
;
Ying HUANG
;
Yu SUN
- Publication Type:Journal Article
- Keywords:
non-small cell lung cancer;
laminin;
calmodulin;
tumor metastasis;
prognosis
- From:Journal of Third Military Medical University
1988;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship of the expression levels of laminin (LN) and calmodulin (CaM) in non-small cell lung carcinoma (NSCLC) with its metastasis and prognosis. Methods The expressions of CaM and LN were detected in 64 human NSCLC samples by immunohistochemistry. Results The expressions of LN and CaM were closely associated with the differentiation and the grades of NSCLC as well as the lymph node metastasis. The positive rates of LN in adenocarcinoma and squamous cell carcinoma were 45.1% and 69.7 (P0.05), respectively. The positive rate of LN protein in low-differentiated samples (36.6%) was significantly lower than that in moderate- to well-differentiated samples (61.7%), but the positive rates of CaM were 73.3% in low-differentiated samples and 41.1% in moderate- to well-differentiated samples (P
