The effect of bezafibrate on serum pro-inflammatory cytokine levels and blood pressure in hypertriglyceridemic and hypertensive patients
- VernacularTitle:苯扎贝特对高甘油三酯血症并高血压患者炎性细胞因子和血压的影响
- Author:
Ping YE
;
Gong SU
;
Cheng ZHANG
- Publication Type:Journal Article
- Keywords:
bezafibrate;
hypertension;
hypertriglyceridemia;
chemokines
- From:
Medical Journal of Chinese People's Liberation Army
1982;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of bezafibrate on serum pro-inflammatory cytokine levels and blood pressure change in patients with hypertriglyceridemia and hypertension after antihypertensive therapy with extended release nifedipine. Methods Fifty-eight patients with both hypertriglyceridemia and hypertension, which was treated with extended release nifedipine, were randomized into 2 groups: bezafibrate group (n=30) and placebo group (n=28). Changes in levels of blood lipids, high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor?(TNF-?) and interleukin-6 (IL-6) were observed following the treatment. A correlation between these changes and blood pressure was analyzed in both groups. Results The levels of triglyceride, total and low density lipoprotein cholesterol were significantly reduced (P
