Plasma D-lactate levels as a useful marker of increased intestinal permeability and gut barrier dysfunction in patients after intraperitoneal operations
- VernacularTitle:应用血浆D-乳酸水平评价腹部外科手术后肠道屏障功能
- Author:
Zhi QIAO
;
Zhanliang LI
;
Jiye LI
- Publication Type:Journal Article
- Keywords:
gut barrier;
digestive system surgical procedures;
lactates;
endotoxins
- From:
Medical Journal of Chinese People's Liberation Army
1982;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the kinetic changes of plasma D-lactate and endotoxin levels in patients after intraperitoneal operations. Methods Blood samples of 63 patients undergoing selective laparotomy were collected 0, 2, 24 and 48h after surgery. According to various criteria, the patients were divided into two groups respectively, i.e. extensive operation or medium sized operation,involvement of gastrointestinal (GI) tract or non-involvement GI tract, and development of symptoms of SIRS or no SIRS after operation. Plasma levels of D-lactate and endotoxin in systemic circulation were determined. Results The analytical data showed that the plasma levels of D-lactate and endotoxin were elevated significantly at 2, 24 and 48h post laparotomy in SIRS patients and major surgery group, and there was also a significant correlation between the plasma levels of D-lactate and endotoxin(?=0.91,P
