Clinical significance of the defermination of serum leptin in patients with post -hepatitis liver cirrhosis
- VernacularTitle:肝炎后肝硬化患者血清瘦素测定的临床意义
- Author:
Xiujuan JIAO
;
Huiqing JIANG
;
Xun PENG
- Publication Type:Journal Article
- Keywords:
Cirrhosis Leptin Nutrition Insulin Insulin resistance
- From:
Chinese Journal of Practical Internal Medicine
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine serum leptin levels and investigate its relatio nship with liver function, insulin resistance and nutritional parameters in pati ents with post-hepatitis liver cirrhosis. Methods Thirty-two ma le patients with post-hepatitis cirrhosis and fourteen male control subjects were enrolled in thi s study. Fasting blood samples were obtained, and serum leptin levels, fasting g lucose and insulin levels were determined in all subjects, and nutritional param e ters were determined in cirrhosis patients. The cirrhosis patients were divided into three groups according to Child-Pugh classification. Results Serum leptin l evels in male hepatic cirrhosis were significantly higher than those of healthy control. There was no significant difference in serum leptin levels among the th ree groups of patients with cirrhosis according to Child-Pugh classification. Se rum insulin levels in male cirrhosis were significantly higher than that of heal thy control. The insulin sensitivity index in cirrhotic patients was decreased c ompared with normal control group. Serum leptin levels in liver cirrhosis were s ignificantly correlated with BMI, TSF and fasting insulin levels, respectively ( r=0.343, 0.340 and 0.352, P
