The influence of hepatitis B virus basic core promoter/precore mutations on adv ance of liver disease.
- VernacularTitle:乙型肝炎病毒基本核心启动子及前C区突变对疾病进展的影响
- Author:
Jilian FANG
;
Xu CONG
;
Ruobing LI
- Publication Type:Journal Article
- Keywords:
Hepatitis B virus Basic core promoter Precore gene Mutat ion Liver disease
- From:
Chinese Journal of Practical Internal Medicine
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between hepatitis B virus (HBV) basic core promoter(BCP)/precore(PreC) mutations and severity of liver dis ease. Methods In 113 patients chronically infected with HBV, do uble mutations in BCP(T1762/A1764) and PreC mutation(A1896) were determined by INNO-LiPA and HB V genotype was determined by S gene sequencing. Results Whether in all patients or in patients infected by single genotype C, compared with AsC, the prevalence of double mutations in BCP(T1762/A1764) was higher in patients with CHB, LC and HCC[(24.1% vs 2.8%,? 2=5.93, P0.05). Conclusions The doubl e mutations in BCP(T1762/A1764 ) may be related to progressive liver disease in patients with chronic HBV infec tion.
