Effects of annexin Ⅱ antisense vector on the growth of transplanted tumor in nude mice
- VernacularTitle:反义annexinⅡ对人肺腺癌细胞系SPC-A-1裸鼠移植瘤生长的抑制作用
- Author:
Jinwei JIA
;
Guisheng QIAN
;
Guijun HUANG
- Publication Type:Journal Article
- Keywords:
annexin Ⅱ;
lung cancer;
nude mouse
- From:Journal of Third Military Medical University
1983;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the effects of annexin Ⅱ antisense expression vector on the growth of the transplanted tumor in nude mice. Methods The SPC-A-1 cells (parental group) and SPC-A-1-annexin Ⅱ cells (antisense group) were inoculated subcutaneously in nude mice respectively. The forming time, volume, and weight of tumor were measured. The tumor cells and the surrounding tissues were observed microscopically. Results The forming time of tumor in the antisense group was later than that in the parental group. The volume and weight of tumor in the antisense group were lower than those in the parental group. Furthermore, invasion of tumor in the surrounding tissues was found in 2 cases in the parental group, but not in the antisense group. Conclusion The annexin Ⅱ gene may be important in promoting tumor cell growth and invading the surrounding tissues.
