Signal transduction and drugtargets for regulating matrix metalloproteinases expression in synoviocytes of rheumatoid arthritis
- VernacularTitle:调节类风湿关节炎滑膜细胞基质金属蛋白酶表达的信号转导和相应的药物作用靶点
- Author:
Yongqiu ZHENG
;
Wei WEI
- Publication Type:Journal Article
- Keywords:
rheumatoid arthritis;
synoviocytes;
matrix metalloproteinases;
signal transduction;
target
- From:
Chinese Pharmacological Bulletin
1987;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Extra-cellular signals, including T lymphoc ytes, cytokines,growth factors,interferons and neuropeptides, which could modulate matrix metalloproteinases expression in synoviocytes of rheumatoid arthritis(RA), are often mediated by G-protein-coupled Receptors (GPCR)-initiated signaling and mitogen-activated protein kinase (MAPK) cascades. Drug targets which aim at the extra-cellular signals or intra-cellular cascades is required for ameliorating inflammatory reaction and preventing joint destruction in RA.
