Relationship between tyrosine protein kinase and synapse plasticity, learning and memory
- VernacularTitle:酪氨酸蛋白激酶与突触可塑性及学习记忆的关系
- Author:
Xin LI
;
Zehui GONG
;
Keliang LIU
- Publication Type:Journal Article
- Keywords:
tyrosine protein kinase;
plasticity;
memory;
trk rece ptor;
src receptor;
eph receptor
- From:
Chinese Pharmacological Bulletin
1987;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, the importance of tyrosine phosphorylation in the nervous system of mammalian is gaining recognition. Tyros ine protein kinases exert important modulatory effect on the proliferation, diff erentiation, migration and metabolism-related singal transduction pathways in c ells. In this paper we reviewed the signal cascade process of three different ty rosine protein kinase families, including Trk, Src and Eph tyrosine protein kina se families. Furthermore, we discussed important role and possible mechanisms of these tyrosine protein kinases on the neuron synapse plasticity and learning an d memory process.
