The ouabain signal transduction and its role in cell growth and death
- VernacularTitle:哇巴因信号的传递及其对细胞生长和死亡的影响
- Author:
Ruicheng XU
;
Min ZHANG
- Publication Type:Journal Article
- Keywords:
ouabain;
signal transduction;
cell growth, cell death
- From:
Chinese Pharmacological Bulletin
1987;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
The ouabain is a member of the cardiotonic steroids (CT S) that specifically bind to Na+,K+-ATPase. Binding of ouabain to Na+,K +-ATPase causes rapid activation of Src family kinases, and forms a Na+,K +-ATPase-Src complex as a active binary receptor to phosphorylate and assem ble other proteins into different signaling modules.Oubain stimulates hypertroph ic growth in cardiac myocytes and proliferation in smooth muscle cells, it also induces apoptosis and a newly recognized "hybrid cell death" of concurrent apopt osis and necrosisin the same cells.
