Effects of 2,3-dimethyl-2-butylamine derivatives on potassium channels in cultured cortical neurons from rats
- VernacularTitle:2,3-二甲基-2-丁胺新衍生物对脑神经细胞钾通道的影响
- Author:
Wenyu CUI
;
Yuping CHEN
;
Hai WANG
- Publication Type:Journal Article
- Keywords:
dimethyl-2-butylamine derivatives;
potassium channels;
cortical neurons;
patch clamp
- From:
Chinese Pharmacological Bulletin
1987;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the effects of newly synthesized 2, 3-dimethyl-2-butylamine derivatives on potassium channels in cortical neurons from rats.Method On cultured cortical neurons, the influences of those novel compounds on I A and I K currents were evaluated using whole-cell patch clamp technique. Result On cortical neurons, these compounds (5),(6),(7),(9) showed no effects on outward potassium currents, while the compounds (4),(8) exhibited inhibition of I K currents. But on a rterial smooth muscle cells(SMCs), all the six compounds had potassium channels opening activities. While the other three compounds had no effects on potassium channels of SMCs, the compound (3) decreased the I K currents evoked on neu rons.Conclusion The novel 2,3-dimethyl-2-butylamine derivati ves had the different modulation of potassium channels on cortical neurons as SM Cs.
