Effects of isoliquiritigenin on cognition dysfunction and brain energy metabolism following repeated cerebral ischemia-reperfusion in mice
- VernacularTitle:异甘草素对脑缺血再灌注小鼠认知功能障碍及能量代谢的影响
- Author:
Chun ZHAN
;
Jing YANG
;
Li ZHAN
;
Lin ZHANG
;
Jing ZHANG
- Publication Type:Journal Article
- Keywords:
isoliquiritigenin;
cerebral ischemia-reperfusion;
ene rgy metabolism;
learning and memory;
reversed-phase high performance liquid chr omatography
- From:
Chinese Pharmacological Bulletin
1987;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the effects of isoliquiritigenin(ISL) on cognition dysfunction and brain energy metabolism following repeated cerebral ischemia-reperfusion in mice.Methods Mouse models of learning and memory deficits were made by repeated occlusion of bilateral common carotid arteries and reperfusion. Step-down test and Y-maze task were used to examine the learning and memory abilities of mice. The brain energy state was analyzed by reversed-phase high performance liquid chromatogra phy. Results ISL 10, 20 and 40 mg?kg -1 ig reduced the n umber of errors and extended the latency of memory in step-down test, decreased the number of cumulated stimulation and increased the number of right choices i n Y-maze task. ISL(10, 20, 40 mg?kg -1) increased the levels of ATP, ener gy charge (EC) and total adenine nucleotides(TAN) in a dose-dependent manner. Conclusion The results suggest that ISL improves cognition dysfun ction induced by repeated cerebral ischemia-reperfusion in mice, which may be r elated to the improvement of brain energy metabolism.
