Effect of adenosine on perilymph glutamate concentration and compound action potentials in guinea pigs exposed to white noise
- VernacularTitle:腺苷对噪声暴露豚鼠耳蜗谷氨酸和复合动作电位的影响
- Author:
Lan ZHANG
;
Xiaoping WANG
;
Chengrong SONG
;
Maohai SONG
;
Jia JIANG
- Publication Type:Journal Article
- Keywords:
adenosine;
glutamate;
noise;
perilymph perfusion
- From:
Academic Journal of Second Military Medical University
1982;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the protective effect of adenosine on cochlea in acute acoustic trauma. Methods: Guinea pigs were exposed to 118 dB SPL white noise for 30 min. During the process of exposure, artificial perilymph or artificial perilymph containing adenosine (0.1 mmol/L,1 mmol/L or 5 mmol/L) was infused into the cochlea through perilymphatic perfusion. Concentration of glutamate in perilymph and thresholds of compound action potentials (CAP) were measured before and after noise exposure. Results: After exposure, the concentration of glutamate and the mean threshold shifts evoked by click were significantly higher than those of before exposure. Concentration of glutamate and thresholds of CAP in adenosine (1 mmol/L and 5 mmol/L) treated groups were significantly lower than those of the control group. Conclusion: Adenosine can inhibit the elevation of glutamate and decrease the threshold shift of CAP after exposure to noise,which can protect cochlea in acute acoustic trauma in guinea pigs.
