Transdermal characteristics of methylphenidate hydrochloride
- VernacularTitle:盐酸哌甲酯的经皮渗透特性研究
- Author:
Yuan YU
;
Yan CHEN
;
Zhiyan ZHANG
;
Shen GAO
;
Xueyin DING
- Publication Type:Journal Article
- Keywords:
methylphenidate hydrochloride;
transdermal delivery;
penetration enhancer
- From:
Academic Journal of Second Military Medical University
1982;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigatethe transdermal delivery characteristics of methylphenidate hydrochloride (MPH) in vitro. Methods: Characteristics of MPH crossing nude rats skin were studied with Franz diffusion cells. A high performance liquid chromatographic (HPLC) method was established to determine the concentration of MPH crossed the skin. The permeability coefficient (P), steady state flux (J) and lag time(LT) for MPH through the skin of nude rats treated with various enhancers were compared with those of control. Results: The permeability coefficient increased with the increase of MPH concentration. The penetration of MPH through nude rats skin was obviously enhanced by 8%Azone and 5%propylene glycol (P
