Expression of calmodulin and its clinical significance in non-small cell lung cancer
- VernacularTitle:钙调素mRNA和蛋白在非小细胞肺癌中的表达及其临床意义
- Author:
Ying HUANG
;
Guoxiang LIU
;
Yu SUN
- Publication Type:Journal Article
- Keywords:
non-small cell lung carcinoma;
calmodulin
- From:Journal of Third Military Medical University
1983;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression level of calmodulin (CaM) in non-small cell lung carcinoma (NSCLC) and its clinical significance. Methods The expression levels of CaM and CaM mRNA were detected in 64 human NSCLC samples by immunohistochemistry and in situ hybridization, respectively. Results The positive rates of CaM mRNA and CaM protein were 60.4% and 65.6%, respectively. The positive rates of CaM mRNA in low-differentiated samples were significantly higher (70.0%) than those in moderate- to well-differentiated samples (45.3%). The expression rates of CaM in Ⅲ-Ⅳ stages (81.8%) were significantly higher than those inⅠ-Ⅱstages (51.6%) (P
