The preliminary study of CT cerebral perfusion imaging on the brain injury of the high +Gx in Rhesus
- VernacularTitle:胸背向过载作用后猴脑部损伤CT灌注成像的初步研究
- Author:
Jun FEI
;
Bin WU
;
Chaoli ZHANG
;
Xiangdong TIAN
;
Cuiping ZHOU
;
Deming ZHAO
- Publication Type:Journal Article
- Keywords:
Hypoxia-ischemia, brain;
Aerospace medicine;
Tomography, X-ray computed;
Animal, experimental
- From:
Chinese Journal of Radiology
2001;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the diagnostic value of CT cerebral perfusion imaging on the brain injury of the high +Gx in Rhesus. Methods Seven healthy male adult Rhesus were randomly divided into control group and +15 Gx group. The +15 Gx group underwent parabolic G curve in animal centrifuge. The animals were all examined by CT cerebral perfusion before +Gx exposure, 2 h, 24 h, and 1 week after ~+Gx exposure. The results were compared with pathologic examination. Results 2 h and 24 h after +15 Gx exposure, brain ischemia was showed on CT cerebral perfusion imaging. After 1 week, the brain ischemia was almost recovered to normal. Mild ischemic atrophy was observed in pyramidal neurons in cerebral cortex by light microscopy. Electron microscopic observation showed chromatin marginating and mitochondria cristae blurring in pyramidal cells after +Gx overload. Conclusion High G from simulating spaceship emergency return can cause ischemic injuries of the brain in Rhesus, and CT brain perfusion imaging can provide valuable diagnostic information.
