Effects of rotenone on mitochondrial potential and cell cycles in PC12 cells
- VernacularTitle:鱼藤酮对PC12细胞线粒体膜电位及细胞周期的影响
- Author:
Yunpeng LI
;
Heping YANG
;
Zhaojun DONG
;
Weidon LE
- Publication Type:Journal Article
- Keywords:
rotenone;
PC12 cell;
mitochondrial potential;
cell cycle;
Parkinson disease
- From:Journal of Third Military Medical University
1984;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of rotenone on the mitochondrial membrane potential and cell cycles in pheochromocytoma (PC12) cells and to explore the injury mechanism of rotenone on dopaminergic neuron. Methods The mitochondrial membrane potential and cell cycles were determined by flow cytometry. Results After treatment with 5.0 ?mol/L rotenone for 12 and 24 h, the percentage of G 0/G 1 phase and S phase in cultured PC12 cells decreased gradually (P
