Roles of nuclear transcription factor ?B in premature delivery associated with infection
- VernacularTitle:NF-?B在小鼠感染性早产发生中作用的研究
- Author:
Xiaoyi YANG
;
Li LI
- Publication Type:Journal Article
- Keywords:
nuclear transcription factor-?B;
infection;
lipopolysaccharide;
preterm delivery;
pyrrolidine dithiocarbamate
- From:Journal of Third Military Medical University
1984;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between nuclear transcription factor-?B (NF-?B) and the preterm delivery (PRD) associated with intraamniotic infection (IAI) and the related mechanisms. Methods A total of 45 pregnant mice (gestation for 15 d) were divided into three groups (n=15 in each group): lipopolysaccharide (LPS) group, pyrrolidine dithiocarbamate (PDTC) plus LPS group, and saline group. The delivery time of the mice administered intravenously with the above in each group was observed after intravenous administration. The other 15 pregnant mice were also divided into 3 groups (n=5 in each group). At 16 h after administration, these mice were sacrificed for the detection of TNF-? and IL-8 levels in the plancenta by immunohistochemistry. Results The gestation time of group administered with LPS was longer than that of the group administered with LPS plus PDTC, but the expression levels of TNF-? and IL-8 were lower than those of the group administered with LPS plus PDTC. Conclusion NF-?B may participate in PRD associated with IAI through modulating the expressions of some cytokines.
