Cerebral ischemia and opioids
- VernacularTitle:缺血性脑卒中与阿片类物质
- Author:
Gang YU
;
Ruibin SU
;
Zehui GONG
- Publication Type:Journal Article
- Keywords:
cerebral ischemia;
opioids;
cerebral vessel;
neuropr o tection;
HPA-axis;
inflammatory reaction
- From:
Chinese Pharmacological Bulletin
1987;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Opioid peptides and their receptors play an important r ole in the pathophysiologic process of stroke. The concentration of endogenous o pioid peptides elevates, while the density of opioid receptors decreases in CNS during cerebral ischemia; on the other hand, opioids influence the development o f stroke through regulating the contraction of cerebral vessel, immuno-endocrin e system and neuroprotection against injury. Thus, drugs that regulate the opioi d system may be a new therapeutic approach for prevention and treatment of cereb ral ischemia.
