Muscarinic M5 receptor subtype and its biologic characterizations
- VernacularTitle:毒蕈碱型M5受体亚型及生物学特性
- Author:
Liyun WANG
;
Jianquan ZHENG
;
Jinxiu RUAN
;
Keliang LIU
- Publication Type:Journal Article
- Keywords:
M5 muscarinic receptor subtype;
signal transductio n;
NO synthase;
DA-ergic nervous pathway
- From:
Chinese Pharmacological Bulletin
1987;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
The fifth muscarinic receptor (M5), the last one of the mus ca rinic receptor family to be cloned, has the same basic formation characterizatio n as G-protein coupled receptor family. M5 transduces signals by coupling with G-proteins, which then modulate the activities of a number of effector enzymes and ion channels. As M5 also plays a variety of prominent physiological roles by regulating central transmitters NO and DA, it has been considered as a novel dr ug therapy target for drug addiction, dysfunction of dopamine-ergic nervous sys tem, Alzheimers disease and cerebral ischemia.
