Structural and functional characterization of snake venom disintegrins
- VernacularTitle:蛇毒解离素的结构特征及其与生物学活性的关系
- Author:
Wei XU
;
Zhiqin LI
;
Shaoyu WU
;
Shuguang WU
- Publication Type:Journal Article
- Keywords:
disintegrin;
integrin;
snake venom
- From:
Chinese Pharmacological Bulletin
1987;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
According to their polypeptide length and number of d is ulphide bonds, disintegrins are divided into five groups, including short-sized disintegrins, medium-sized disintegrins, long-sized disintegrins, dimeric dis integrins and disintegrin-like molecules released from the disintegrin-like do mains of P-III snake venom metalloproteinases. The integrin-inhibitory activit y of disintegrins, to inhibit platelet aggregating, cell attaching and angiogene sis, depends on the active tripeptide RGD, the appropriate pairing of cysteine r esidues, the amino acids adjacent to the RGD motif within the integrin-binding loop and the C-terminus of the disintegrin polypeptidesl as well.
