Rosiglitazone enhanced growth inhibition of cisplatin in hunman lung adenocarcinoma cell
- VernacularTitle:罗格列酮增强顺铂抑制人肺腺癌细胞增殖作用
- Author:
Tingfang ZHOU
;
Yingzhi ZHUANG
;
Jianguo CAO
- Publication Type:Journal Article
- Keywords:
lung adenocarcinoma;
rosiglitazone;
cisplatin;
chemosens itization
- From:
Chinese Pharmacological Bulletin
1987;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
1.15). Rosiglitazone at the concentration of 1.25 ?mol?L -1 augme nted the induction apoptosis of A549 cells by treatment with Cisplatin at variou s concentrations of 1.98 mg?L -1, 2.8 mg?L -1 and 4.0 mg?L -1 . A549 cells treated with Rosiglitazone at concentration of 1.25 ?mol?L -1 domostrated nuclear traslocations of PPAR? protein and down-regulation of Bcl-2 protein. Conclusion The ligand of PPAR? Rosiglitazone enhanc ed the inhibition of proliferation and induction of apoptosis by treatment with Cisplatin in A549 cells cultured in vitro. Activation of PPAR? protein and the down-regulation of Bcl-2 possiblely play an improtant role in chemosenstiz eic mechanism of Rosiglitazone in vitro.
