Inhibitory effect of Garlic Polysaccharide on adriamycin-induced cardiotoxicity in mice
- VernacularTitle:大蒜多糖对阿霉素所致小鼠心脏毒性的拮抗作用
- Author:
Wei YU
;
Jiliang WU
;
Hui WANG
- Publication Type:Journal Article
- Keywords:
garlic polysaccharide;
adriamycin;
cardiotoxicity;
lip id peroxidation
- From:
Chinese Pharmacological Bulletin
1987;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To study the inhibitory effects and its mechanis ms of Garlic Polysaccharide (GP) on adriamycin(ADR)-induced cardiotoxicity in mic e.Mehtod ADR was injected intraperitoneally to induce myocardiu m injury model in mice. The activities of several serum and heart tissue enzymes were measured. With scanning electron microscope, the cardiac ultrastructural c hanges were examined.Results ADR (3 mg?kg -1 ip, qod?7) induced severe myocardial damages with the increasing activities of creatine kin ase (CK), lactate dehydrogenase (LDH), glutamic oxaloacetic transaminase (GOT) a nd inducible nitric oxide synthase (iNOS) (P
