The effects of topiramate on the epileptiform discharge and related neurotrans mitters in hippocampus in seizure rats induced by penicillin
- VernacularTitle:托吡酯对青霉素诱发大鼠痫性放电和海马区相关递质含量的影响
- Author:
Rong YANG
;
Mingzheng WANG
;
Yinxia CHENG
;
Yueqin LIANG
- Publication Type:Journal Article
- Keywords:
topiramate;
penicillin-induced;
epileptiform discharg e;
neurotransmitters related to epilepsy
- From:
Chinese Pharmacological Bulletin
1987;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the effects of topiramate (TPM) o n the model of seizure rats induced by penicillin and explore its mechanism of ant iconvulsant action.Methods Using the model of seizure rats indu ced by penicillin localized injected in cortex, we investigated the effect of TP M on the changes of seizure extent and recorded the latency of epileptiform disc harge, frequency of epileptiform wave, highest wave of hippocampus EEG. The leve ls of Glu, Asp, Gly and GABA in hippocampus were determined by high performance liquid chromatography (HPLC). Results Compared with the model g roup, TPM (110 mg?kg -1, 440 mg?kg -1, ig) could significantly light ened the extent of seizure, prolonged the latency of epileptiform discharge, red uced the frequency of epileptiform wave and minished the highest wave of hippoca mpus EEG (P
