A study on the antibacterial activity of cefathiamidine combined with ciprofloxacin against Gram-positive cocci
- VernacularTitle:头孢硫脒与环丙沙星对革兰阳性球菌的联合药敏研究
- Author:
Dong CHAI
;
Fei PEI
;
Yi FANG
;
Rui WANG
- Publication Type:Journal Article
- Keywords:
cefathiamidine;
gram-positive cocci;
FIC
- From:
Chinese Pharmacological Bulletin
1987;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To study the in virto interaction o f Cefathiamidine in combination with Ciprofloxacin against clinical isolates of Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis. Methods The activity of each drug alone was determined against all the isolates. Chequerborad synergy testing was then performed against all the isolat es. Results The percentage of the FIC index less than 0.5, from 0.5 t o 1,from 1 to 2,more than 2 was 53.3%～93.3%,6.7%～46.7%,0%,0% respectiv ely. Conclusion Synergism and additivity of cefathiamidine comb ined with ciprofloxacin respectively against 90 strains of Gram positive cocci w ere the main inter actions, there were little autonomy and no antagonism.
