Effects of naoyikang on capability of learning and memory in Alzheimer’s disease model mice
- VernacularTitle:脑益康对阿尔茨海默病模型小鼠学习记忆的影响
- Author:
Yan ZHU
;
AiLing ZHOU
;
JiaHui MAO
- Publication Type:Journal Article
- Keywords:
Alzheimer’s disease;
animal model;
naoyikang;
learning and memory;
superoxide dismutase;
malondialdehyde
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2000;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM : To observe the effects of naoyikang on the capability of learning and memory in Alzheimer’s disease model mice. METHODS : The mice model was established by intraperitoneal injection of D BZ Gal and NaNO 2, the capability of learning and memory was tested on mice by electrical maze and water maze, the levels of superoxide dismutase (SOD) and malondialdehyde(MDA) of brain tissues were assayed by biochemical methods,and the changes in ultrastructure were observed by Transmission Electron Microscope. RESULTS : The capability of learning and memory of model mice decreased and the level of SOD of model mice decreased and MDA increased. Compared with the madel group, they were obviously improved in low, middle and high doses ( 2.4 , 7.2 , 24 g?kg -1 ?d -1 ) of naoyikang group ([WTBX P
