Human adjuvant disease manifesting as SLE.
- Author:
Ja Hun JUNG
1
;
Sung Soo JUNG
;
Hee Sig MUN
;
Yong Ho SONG
;
Young Jung CHO
;
Kwang Taek OH
;
Tae Hwan KIM
;
Jae Bum JUN
;
In Hong LEE
;
Sang Cheol BAE
;
Dae Hyun YOO
;
Seong Yoon KIM
Author Information
1. Rheumatism Center, Department of Internal Medicine, College of Medicine, Hanyang University, Seoul, Korea.
- Publication Type:Case Report
- Keywords:
Human adjuvant disease;
SLE;
silicone
- MeSH:
Adult;
Arthritis, Rheumatoid;
Autoimmune Diseases;
Female;
Foreign Bodies;
Humans*;
Japan;
Mammaplasty;
Polymyositis;
Silicones;
Surgery, Plastic;
Thyroid Gland;
Thyroiditis
- From:Korean Journal of Medicine
1998;54(2):246-252
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Human adjuvant disease means the autoimmune disease or autoimmune disease like syndrome developed after plastic surgery using foreign body implantation. After first report of HAD by Miyoshi at 1964, a number of cases have been reported especially from Japan. Silicone has been known as biologically inert material, but a couple of side reaction and experimental data argue against such conventional idea. It is impossible to identify the exact role of implanted substance in the occurrence of autoimmune disease, but there are a few indirect evidences for adjuvant effect of silicone. The spectrum of HAD are as follows: unclassifiable connective disease like syndrome, rheumatoid arthritis, SLE, polymyositis, adult Still's disease, ITP, Hashimoto's thyroiditis, etc. We experienced two cases of HAD manifesting as SLE who had been injected with silicone fluid with for augmentation mammoplasty and report this with a review of the literature.
