Randomized clinical trial on chemoradiotherapy in locally advanced non small cell lung cancer
- VernacularTitle:局部晚期非小细胞肺癌放疗与化放综合治疗对比研究
- Author:
Chunbo WANG
;
Ruizhi WANG
;
Qingfeng ZHANG
;
Hongtao ZHANG
- Publication Type:Journal Article
- Keywords:
Carcinoma, non-small cell lung/radiotherapy;
Carcinoma, non-small cell lung/chemotherapy;
Combine modality therapy;
Prognosis
- From:
Chinese Journal of Radiation Oncology
1992;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of chemoradiotherapy for stage Ⅲ non small cell lung cancer (NSCLC). Methods From January 1995 to December 2000, 132 patients with stage Ⅲ NSCLC were randomized into two groups: radiotherapy alone group (RT, 65 patioents), treated by conventional fractionation to a total dose of D_T 60?Gy～70?Gy/6 w～7 w; Chemoradiotherapy group (CRT, 67 patients), with chemotherapy given concomitantly or alternately with RT for at least 2 courses. Results Complete response rates of RT and CRT group were 14% and 27%, respectively. Disease progression rates of the two groups were 18% and 13%. The 1-,3-and 5-year survival rates were 62.1%, 22.7%, 9.3%and 52.7%, 9.3%, 6.9% in CRT and RT groups(P
