A Case of Drug-Induced Acute Interstitial Nephritis Accompanying Prominent Neutrophil Infiltration.
- Author:
Tae Rim SHIN
1
;
Mi Sun KIM
;
Eun Soon HONG
;
Eun Young LEE
;
Duk Hee KANG
;
Gyu Bock CHOI
;
Kyun Il YOON
;
Soon Hee SUNG
Author Information
1. Department of Internal Medicine, College of Medicine, Ewha Womans University, Seoul, Korea.
- Publication Type:Case Report
- Keywords:
interstitial nephritis;
drug-induced;
thiazide diuretic
- MeSH:
Acute Kidney Injury;
Biopsy;
Diagnosis;
Diuretics;
Female;
Humans;
Hydrochlorothiazide;
Hypertension;
Methicillin;
Middle Aged;
Nephritis, Interstitial*;
Neutrophil Infiltration*;
Neutrophils*;
Penicillins
- From:Korean Journal of Medicine
1998;54(2):261-265
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Drug-induced acute interstitial nephritis, induced by unknown immunologic mechanisms, is inflammatory lesions of the tubulointerstitial area due to several kinds of drugs as hapten and a rare, but increasingly recognized cause of acute renal failure. Drugs implicated include not only methicillin and other penicillins but also diuretics and nonsteroidal anti-imflammatory agents. Diagnosis of acute interstitial nephritis is important, because withdrawal of the offending agent will usually result in rapid improvement in renal function, and steroid therapy may reduce residual chronic renal damage. We are reporting a case of diuretic-induced acute interstitial nephritis in a 49 year-old female patient, who was given hydrochlorothiazide to treat hypertension. A percutaneous biopsy showed tubulointerstitial nephritis accopanying prominent neutrophil infiltration without glomerulitis. Withdrawal of the drug and use of corticosteroid led to remarkable improvement with renal function returning to normal.
