The changes in proinflammatory cytokines in the circulation following acute pulmonary thromboembolism in dogs
- VernacularTitle:急性肺血栓栓塞早期血循环中致炎细胞因子变化的实验研究
- Author:
Wenbing LI
;
Dewei GAO
;
Senyang YU
- Publication Type:Journal Article
- Keywords:
respiratory distress syndrome, adult;
chemokines;
inflammation;
pulmonary embolism
- From:
Medical Journal of Chinese People's Liberation Army
1982;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective In the present study we examined the roles of three proinflammatory cytokines, i.e. tumor necrosis factor-?(TNF-?), interleukin 1?(IL-1?), and IL-8 in the early phase of APTE, and analyze the impact of these cytokines on the systemic circulation. Methods APTE was induced in 7 anesthetized dogs by injecting the thrombus of own blood into the right jugular vein. Seven animals receiving only warm sterile saline served as controls. Arterial serum samples were collected regularly (0h, 0.5h, 1h, 2h, 4h, 6h) and cytokine levels could be measured by radio-immunity assay. Results Introduction of clots into the pulmonary circulation caused significant increase in the mean pulmonary arterial pressure(from 99.1?5.7 to 66.8?15.3mmHg, P
