Propofol proteets liver in hypoxia/reoxygenation injury in rats
- VernacularTitle:异丙酚对大鼠肝脏缺氧复氧损伤的保护作用
- Author:
Yingjie SUN
;
Guangjie GAO
;
Tiezheng ZHANG
- Publication Type:Journal Article
- Keywords:
propofol;
liver;
hypoxia/reoxygenation;
8-iso-PGF 2?;
NOS;
NO
- From:
Medical Journal of Chinese People's Liberation Army
1982;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the protective effects of propofol on liver against hypoxia/reoxgenation (H/R) injury in rats. Methods Twenty-four Wistar rats of both sexet weighing 200-250g were randomized into control group (group A), hypoxia/reoxygenation group (group B) and H/R + propofol group (group C). The 8-iso-prostaglandin F 2? (8-iso-PGF 2? ) level in the hepatic tissue was determined by enzyme-linked immunosorbent assay (ELISA). The content of NO and the activity of NOS were assessed by biochemical methods. Results In group B, the 8-iso-PGF 2? level in hepatic tissue was significantly higher than that in group A (P
