Study on cellular immune response to large-dose HBsAg vaccine in transgenic mice
- VernacularTitle:大剂量HBsAg疫苗对HBV转基因小鼠细胞免疫调节的研究
- Author:
Huiping LIU
;
Yili XIONG
;
Li SHI
- Publication Type:Journal Article
- Keywords:
HBsAg;
Tg;
mice DC;
proliferation;
cytokine
- From:
Medical Journal of Chinese People's Liberation Army
1982;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the cellular immune response to a large-dose of HBsAg vaccine in transgenic (Tg) mice. Method After the Tg mice was immunized with HBsAg vaccine, the number of dentritic cells (DC), the level of proliferation of T-lymphocytes, and the production of IL-2 and IFN-?were determined. Results The percentage of cells positive for common stimulating factors CD80, CD86, and I-E k were significantly higher than that of the control group (P
