The effect of blood pressure elevation on the enlargement of saccular aneurysm and its mechanism: an experimental study
- VernacularTitle:血压在囊性动脉瘤增大中的作用及作用机制的实验研究
- Author:
Zhenghui SUN
;
Bainan XU
;
Dingbiao ZHOU
- Publication Type:Journal Article
- Keywords:
blood pressure;
aneurysm, saccular;
carotid artery, external;
fibroblast growth factor, basic
- From:
Medical Journal of Chinese People's Liberation Army
1982;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective to study the effect of blood pressure on the enlargement of saccular aneurysm and its mechanism. Methods Forty-eight SD rats were divided into 3 groups randomly(A, B and C; n=16 in each group). Saccular aneurysms of the carotid artery were induced by corrosion of the initial segment of the external carotid artery (1mm long) with elastase. In group A, the posterior branches of both renal arteries were ligated in order to produce a marlced blood pressure elevation. In group B, only unilateral renal artery was ligated, and a moderate hypertension was produced. In group C high blood pressure was not produced to serve as the control group. After 2 and 8 weeks, the blood pressure and the size of the aneurysms were measured. Then the aneurysms were fixed by intraarterial perfusion of formalin and were harvested for examinations. The expression of basic fibroblast growth factor (bFGF) in aneurismal wall was determined by immunohistochemical analysis. Results Two weeks after the beginning of the experiment, there was no difference in size of aneurysm among the 3 groups. But after 8 weeks, significant difference in aneurysmal size was found between group A and the other two groups. The expression of bFGF in group A was stronger than that in group B and C. Conclusion The elevation of blood pressure and enhancement of bFGF expression in aneurismal wall play an important role in enlargement of the aneurysm.
