Dynamic contrast-enhanced MR of the prostatic cancer and benign prostatic hyperplasia: correlation with angiogenesis
- VernacularTitle:前列腺癌与良性前列腺增生症的MR动态增强与血管生成的相关性研究
- Author:
Xinchu NI
;
Junkang SHEN
;
Zhian LU
;
Nong QIAN
;
Lijuan ZHOU
;
Xiaochun YANG
;
Guanzhong WANG
;
Caiyuan ZHANG
;
Shuizhen WANG
;
Jianbo XIANG
;
Changjie PAN
;
Weiliang RONG
;
Jianguo CHEN
;
Yuxi SHAN
;
Minghui QIAN
- Publication Type:Journal Article
- Keywords:
Prostatic neoplasms;
Prostatic hyperplasia;
Magnetic resonance imaging;
Image enhancement;
Angiogenesis factor
- From:
Chinese Journal of Radiology
2001;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the role of dynamic contrast-enhanced magnetic resonance imaging (MRI) in the diagnose of prostatic cancer and benign prostatic hyperplasia (BPH), and to determine the correlation between dynamic MRI findings with angiogenesis.Methods Thirty-two cases of prostatic cancer and 40 cases of BPH underwent dynamic contrast-enhanced MRI.All the patients in this study were diagnosed by histopathology.The results of dynamic contrast-enhanced MRI were evaluated by early-phase enhancement parameters and time-signal intensity curves (SI-T curves), and the curves were classified according to their shapes as type Ⅰ, which had steady enhancement; type Ⅱ, plateau of signal intensity; and type Ⅲ, washout of signal intensity.The pathologic specimens of region of interest (ROI) were obtained, and HE staining, immunohistochemical vascular endothelial growth factor (VEGF), and microvessel density (MVD) measurements were performed.The relationships among dynamic contrast-enhanced MRI features, VEGF, and MVD expression were analyzed.Results In the early-phase enhancement parameters of dynamic contrast-enhanced MRI, onset time,maximum signal intensity, and early-phase enhancement rate differed between prostatic cancer and BPH(P
