Multiple modality endovascular treatment for intracranial venous thrombosis
- VernacularTitle:多途径联合血管内治疗颅内静脉窦血栓形成
- Author:
Xunming JI
;
Feng LING
;
Jianping JIA
;
Shenmao LI
;
Zhongrong MIAO
;
Fengshui ZHU
;
Yingying SU
;
Baoquan MIN
;
Xiangbo WANG
;
Hongqi ZHANG
;
Peng ZHANG
;
Xinglong ZHI
;
Qingbin SONG
;
Xiaohong QIN
;
Xiangmei LIU
;
Hong ZHANG
- Publication Type:Journal Article
- Keywords:
Sinus thrombosis, intracranial;
Thrombolytic therapy;
Treatment outcome
- From:
Chinese Journal of Radiology
2001;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To review the experience of multiple modality endovascular treatment for intracranial venous thrombosis, and to evaluate the efficacy and risk of endovascular thrombolysis for intracranial venous thrombosis.Methods From October, 2000 to October, 2001, 12 patients with intracranial venous thrombosis confirmed by CT, MRI, MRV, and/or DSA were treated with multiple modality endovascular thrombolysis including intravenous thrombolysis, mechanical thrombus maceration, intraarterial thrombolysis, and stenting.After thrombolysis, treatment aimed at the primary diseases was continued and warfarin was used for 6 months.The patients were followed-up for 17-29 months, averaged 23 months.Results Of the twelve patients, all underwent transvenous thrombolysis, ten underwent combined transvenous thrombolysis and clot maceration, seven underwent transvenous infusion of urokinase combined with transarterial infusion of urokinase.Two underwent transvenous infusion of urokinase combined with transarterial infusion of urokinase.The thrombolysis duration was from one to three days.The infusion dose of urokinase was 800 000 to 2 900 000 IU, the averaging dosage of urokinase was less than 1 000 000 IU per day.All patients achieved from recanalization of sinuses as confirmed on postprocedural angiography, MRI, and MRV studies prior to hospital discharge.At discharge, all the patients improved neurologically, and GCS improved from averaged 12 of pre-operation to 14 of post-operation.During the averaging 23 months follow-up, no patient recurred. Conclusion Combined multiple modality endovascular treatment is an effective and safe procedure for potentially catastrophic intracranial venous thrombosis.
