Therapeutic efficacy of gemcitabine combined with cisplatin for advanced non-small cell lung cancer
- VernacularTitle:健择+顺铂方案治疗晚期非小细胞肺癌临床疗效观察
- Author:
Yanling ZHANG
;
Zhiheng BIAN
;
Wenwei ZUO
;
Houjie LIANG
- Publication Type:Journal Article
- Keywords:
non-small cell lung cancer;
chemotherapy;
gemcitabine;
cisplatin
- From:Journal of Third Military Medical University
2003;0(24):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy and toxicity of the combination of gemcitabine and cisplatin in the treatment of patients with advanced non-small cell lung cancer (NSCLC). Methods A total of 30 cases of non-small cell lung cancer (stages Ⅲ and Ⅳ) were treated with gemcitabine (1 200 mg/m 2, iv infusion, at 1 and 8 d) and cisplatin (100 mg/m 2, iv infusion, at 1 d or cisplatin at 30 mg/m 2, iv infusion, at 1 and 8 d). The administration course was 28 d. Results An objective response was obtained in 46.67% of patients (2 complete and 12 partial responses), whereas 11 patients had no change and 5 patients were progressive. The response rate was 52.38% in patients with no prior chemotherapy and the response rate of 33.33% was achieved in patients who had been given prior treatment. There was significant difference between the two groups (P
